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Background and Importance Medication-related problems (MRPs) are situations in the process of using medicines or healthcare products (HCPs) that cause or may cause a negative medication-related outcome (NMRO). These errors can occur due to omissions, duplications, incorrect doses or adverse reactions. In Spain, they account for 10-30% of emergency department (ED) visits, causing high morbidity and mortality among patients and significant economic costs for the national health system for preventable reasonsAim and Objectives Analyse PRMs in patients attending the emergency department for observationMaterial and Methods Retrospective observational study of patients who attended for observation between 01/01/2025 and 19/09/2025 whose reason for consultation was PRM. Demographic (age, sex), clinical (reason for attending the emergency department), pharmacological (medication reconciled, drug involved and its ATC classification), PRM (classification according to the Second Granada Consensus on PRM) and type of adverse reaction (RAM) according to the organ affected (classification from the technical data sheet). The data were extracted from the medical record, from consultations with the pharmacy, and from the list of medications on the electronic prescriptionBoth quantitative and qualitative variables were expressed as absolute frequencies and percentagesResults 99 patients presented with PRM, of whom 52 (53%) were women. The median age was 78 years (RI: 22-103). 19.72% of patients who attended the emergency department did so because of PRM72% PRM due to non-quantitative insecurity, 14% quantitative insecurity, 7% quantitative inefficiency, 6% did not receive necessary treatment, and 1% received unnecessary treatment.29% of ADRs affected the digestive system, 11% affected electrolyte imbalances, 10% affected infections, 10% affected renal disorders, and 10% affected respiratory disorders. 30% affected other systems.According to the ATC classification, 28% of the drugs involved belong to the nervous system group, 15% to the alimentary tract and metabolism group, 14% to the cardiovascular system group, 9% to the anti-infective group, 9% to the antineoplastic group, and 25% to other ATC groupsConclusion and Relevance Early detection of medication errors reduces the problems arising from them, improving safety and clinical outcomes, reducing the burden of care in emergency departments due to preventable causes, and reducing hospital admissionsConflict of Interest No conflict of interest