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237 A novel form of geographic specific reflex epilepsy

jnnp · 2025-11-26 · canonical JSON source

2 visible annotations · policy: published · automated confidence ≥ 75.00%

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We present a case of a ‘Location specific reflex epilepsy’ of temporal lobe semiology aggravated by a particular geographical location and visual scene which has been captured in ambulatory EEG in a 34yr women. Patient started having stereotypical complex partial seizures initiating with a particular sequence of nausea resulting in dejavu further evolving from focal to bilateral tonic-clonic seizures. Seizures were mainly triggered in a specific geographical region as episodes occurred when she is driving up the road to her house in Omagh. In addition she has history of nocturnal seizures triggered when she had a dream of driving along the same lane from her home town going up towards family house. Brain MRI showed no epileptogenic lesion and inter-ictal EEG showed bilateral independent epileptiform discharges over temporal regions, with a left-sided emphasis. Clinical seizure was captured on ambulatory EEG whilst travelling along the same lane in Omagh. The fact that her seizures occur in a specific situation is exceptionally rare and to this date only one other case has ever been reported in the literature similar to ours. Patient responded well to Lamotrigine. Pathophysiology of reflex epilepsies postulates that simple triggers activate specific cortical regions in a circumscribed manner but complex stimuli may activate wider functional circuits where hyper-excitable areas could overlap with areas activated by specific stimuli. Further study of aberrant network dysfunction is required in such individuals.dhruvock27@yahoo.com