Document resource
Background and Aims To explore the synergistic analgesic mechanism of combining lidocaine, ropivacaine, and morphine in epidural injections and its advantages in postoperative pain management.Methods A prospective, randomized, double-blind trial included 120 abdominal surgery patients (18–65 years). The experimental group (n=60) received epidural lidocaine (0.75%, 10 ml), ropivacaine (0.75%, 10 ml), and low-dose morphine (0.03 mg/kg); the control group (n=60) received only lidocaine and ropivacaine. Pain scores, morphine consumption, side effects, and satisfaction were recorded for 48 hours postoperatively.Results The experimental group had significantly lower pain scores at 6 h (1.8±0.9), 12 h (2.0±1.0), 24 h (2.2±1.1), and 48 h (2.1±1.3) compared to the control group (4.7±1.2, 4.8±1.3, 4.6±1.4, 4.8±1.5; P<0.001). Morphine consumption was lower (25±10 mg vs. 50±15 mg, P<0.001), and side effects (nausea/vomiting: 12% vs. 35%, P<0.01) were reduced. Patient satisfaction was higher (4.6±0.5 vs. 3.2±0.8, P<0.001).Conclusions The combination of lidocaine, ropivacaine, and morphine enhances postoperative analgesia, reduces morphine use and side effects, and improves patient satisfaction, making it a recommended strategy for epidural anesthesia.