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Objective EuroJEM aims to provide comprehensive, state-of-the-art occupational exposure assessment data to support population-based studies across Europe.Material and Methods A systematic search was conducted to identify national Job-Exposure Matrices (JEMs) and relevant source data suitable for developing a unified European exposure framework. Three expert panels were established to lead harmonization efforts in chemical and particulate exposures, physical exposures, and psychosocial and ergonomic conditions. Where national JEMs were limited or absent, new matrices were developed. All partners contributed to aligning exposure assignments and occupational coding systems. EuroJEM 1.0 is coded using the European version of the International Standard Classification of Occupations, 1988 edition (ISCO-88(COM)) to ensure compatibility with cohort data.Results The result is a multidimensional JEM covering a broad range of occupational exposures, including:Chemicals and particlesHeat stressNoisePhysical workloadPrecarious employmentPsychosocial working conditionsSolar UV radiationAirborne infectious agentsA dedicated website (http://ki.se/en/imm/eurojem) provides access to EuroJEM’s content, usage guidelines, and tools for researchers and policymakers. The infrastructure is designed to evolve, with ongoing updates and new matrices added as new data and exposure risks emerge.Conclusion EuroJEM 1.0 represents a major step forward in harmonizing occupational exposure data across Europe. Its integration of multiple exposure domains and use of standardized coding systems offers a valuable resource for occupational health research and policy. However, as current data are largely derived from Nordic and Western European sources, caution is advised when applying the matrix to Eastern European contexts. Continued development will enhance EuroJEM’s scope, ensuring its relevance and reliability across the continent.