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To describe the spectrum, frequency, and clinical outcomes of GI manifestations in patients with genetically confirmed DiGeorge syndrome at a single tertiary care centre.We retrospectively reviewed medical records of patients with confirmed DiGeorge syndrome followed at our centre from January 2010 to July 2025. Data collected included demographic details, genetic confirmation, GI symptoms, endoscopic/radiologic findings, motility study results (where performed), interventions, and outcomes.Twenty patients (13 males, 7 females), all diagnosed within the first year of life, were included. Gastro-intestinal( GI) manifestations were observed in all patients (100%). Common presentations included gastroesophageal reflux disease (GORD) in 16 (80%), feeding difficulties in 13 (65%), and chronic constipation in 9 (45%). Structural anomalies were identified in 3 patients: oesophageal atresia in 2 (10%) and anorectal malformation in 1 (5%), all of whom underwent corrective surgery.Nutritional compromise was documented in 15 patients (75%), often compounded by endocrine-related growth failure. Feeding team input played a key role in initiating and optimising nutritional support. All patients received multidisciplinary care involving gastroenterology, cardiology, immunology, and nutrition services.Symptom resolution was achieved in only 7 patients (35%), while others had persistent but improved symptoms. Two patients underwent thymic transplantation.GI manifestations are highly prevalent in children with DiGeorge syndrome and encompass both functional and structural disorders. Nutritional challenges are common, and targeted feeding support can significantly improve growth and quality of life. Early recognition and multidisciplinary management are essential to reduce morbidity and enhance long-term outcomes.