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Introduction While randomized clinical trials have established mechanical thrombectomy as an effective treatment for acute ischemic stroke with large vessel occlusion (LVO), limited evidence exists regarding factors influencing prolonged hospitalization in thrombectomy patients. The TICI (Thrombolysis in Cerebral Infarction) scale is an angiographic grading system that assesses the degree of reperfusion achieved following endovascular intervention.This study investigates clinical and procedural characteristics associated with extended hospital stays following endovascular stroke therapy.Aim of Study Therefore, the objective of this study is to analyze potential factors associated with reduced hospital length of stay.Method We conducted a retrospective cohort study including patients aged ≥18 years presenting with acute ischemic stroke due to large vessel occlusion and treated with mechanical thrombectomy within 24 hours of symptom onset.Results Two hundred seventy-seven patients were included in the analysis. Two hundred twenty-eight patients (82.3%) achieved successful recanalization (TICI 2b-3) with a mortality rate of 25.8%, compared to forty-nine patients (17.7%) with poor recanalization (TICI 0–2a) who showed a mortality rate of 55.1% (OR 3.23; [95% CI], 1.69–6.19; P<0.001)The group of patients who received sedation had lower mortality compared to the general anesthesia group (OR 0.41 [95% CI], 0.23–0.70; P=0.001)Conclusion When comparing the number of discharges of alive patients during the first 10 days post-thrombectomy between the successful recanalization group (TICI 2b and 3) and the poor recanalization group (TICI 0–2a), no statistically significant differences were found. However, a difference in mortality was found between the groups.Conflict of Interest No