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We read with interest the review by de Vos et al.1 The human gut microbiome plays a pivotal role in the maintenance of health and the development of disease.2 3 With the growing availability of microbiome testing products and publications, some patients feel that their health problems are not fully understood or addressed by doctors using conventional medical approaches.4 Concomitantly with a rise in consumer interest in self-testing, questions have emerged regarding the scientific validity, regulatory status and clinical interpretability of microbiome testing kits.5 6 In this context, we aimed to evaluate, on a nationwide French scale, the methods employed, the nature and quality of the results obtained, and the putative benefits that non-specialists/patients can derive from these readily accessible microbiota analyses.