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Annotated abstract

Novel implantable anesthetic for spine fixation surgery: phase Ib safety results of a sustained-release formulation of bupivacaine

rapm · 2026-05-04 · canonical JSON source

3 visible annotations · policy: published · automated confidence ≥ 75.00%

Document resource

In spine fixation surgery, patients frequently suffer severe postoperative pain for several days. 1 For decades, opioids have been the dominant pain therapy despite their side effects and addictive properties. Poor postoperative pain control prevents early mobilization and recovery, resulting in worse clinical outcomes, higher costs, and extended hospital stays.2 Local anesthetics are increasingly used to reduce opioids and promote enhanced recovery, but work too short for spine fixation procedures.3