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Iatrogenic palatal perforation in infants is a rare but serious complication that can lead to feeding difficulties, aspiration and inadequate weight gain. This case report describes an infant who developed a palatal defect following hospitalisation for an acute febrile illness. After ruling out congenital and infectious aetiologies, the perforation was considered likely to be iatrogenic secondary to orotracheal intubation. A self-retentive feeding plate was fabricated and fitted to improve feeding and prevent further complications. The appliance effectively restored feeding efficiency, reduced nasal regurgitation and facilitated spontaneous healing. Over 1 month, the defect size diminished significantly, reflecting the regenerative capacity of oral tissues. This case report emphasises the importance of careful airway management, early prosthetic intervention and a multidisciplinary approach in managing such neonatal complications.