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In palliative care, we can often predict that a patient is entering a deteriorating phase and the prognosis is limited. We can also anticipate a shift from the oral route to the parental route using continuous subcutaneous infusion (CSCI) as this deterioration progresses. However, how should we appropriately manage medications such as antidepressants that are not amenable to administration by CSCI? Should we proactively deprescribe or dose-reduce such medications to minimise well-recognised issues associated with their abrupt cessation?