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Objective This study aims to explore the association of greenspace exposure (PGE) with quality of life (QoL) and mental health among non-healthcare workers.Material and Methods We conducted a cross-sectional survey on occupational and environmental influences on QoL of non-healthcare workers in Hong Kong during 12/2023 – 12/2024. Information on demographics, lifestyle behaviors, occupational history and perceived environmental factors was collected by online questionnaires. We measured PGE using self-reported questionnaires about greenspace abundance, visibility, access and usage near participants’ homes/workplace. We assessed relationships between PGE and QoL using multiple linear models and logistic regression models.Results Totaling 547 (39.6%) from 1380 participants were male, the mean physical composite scores (PCS) of 46.1 and the mean mental composite scores (MCS) of 50.6. 300 (21.7%) participants were found with stress symptom, 512 (37.1%) with anxiety symptom and 419 (30.4%) with depression symptom. Positive relationships between MCS and PGE3 (0.54, 95%CI: 0.11-0.96) were observed. Significant negative associations of anxiety and depression with PGE3 were also observed (odds ratio [OR]=0.93, 95% CI: 0.87-0.99 for anxiety; 0.93, 0.87-0.998 for depression). Subgroup analyses showed that PGE played different roles on workers with different genders and ages.Conclusion This study suggests that PGE plays a vital role in enhancing the quality of life and promoting mental health. (Funding: HMRF Ref.: COVID190104, COVID1903008, and 18190471).