Document resource
Background Ventilatory efficiency (VE) from cardiopulmonary exercise testing (CPET) is a valuable prognostic metric for evaluating cardiopulmonary diseases. However, its relationship with clinical outcomes in hypersensitivity pneumonitis (HP) remains unclear. We aimed to determine whether VE correlates with disease severity and predicts mortality in HP.Research question In patients with HP, does VE correlate with disease severity and predict mortality?Methods This retrospective cohort study (2009–2019) included patients with non-fibrotic (nfHP) and fibrotic HP (fHP) and idiopathic pulmonary fibrosis (IPF), which served as the comparison group. CPET variables, including VE/carbon dioxide (VE/VCO 2), were assessed across various forced vital capacity (FVC%) and diffusing capacity for carbon monoxide (DLCO%) ranges. Multivariate logistic regression identified predictors of 5-year mortality and survival was assessed with Kaplan-Meier plots.Results 164 patients were analysed (mean age of 65.6±12.0 years, 54.3% male). 25 had nfHP, 66 fHP and 73 IPF. Overall, an increase in the VE/VCO 2 slope and nadir was observed as the DLCO% decreased, but not with a decrease in FVC%, while the intercept remained unchanged. Patients with pulmonary hypertension (35%, 57/164) and fHP or IPF had significantly higher VE/VCO2 slope and nadir when compared with patients without pulmonary hypertension or nfHP, respectively. A VE/VCO2 slope ≥42 predicted survival (HR 3.65; 95% CI 1.04 to 12.80). Restricting the analysis to patients with HP showed similar results (HR 5.49; 95% CI 1.19 to 33.54).Interpretation In patients with HP, elevated VE/VCO 2 is associated with the presence of pulmonary fibrosis, PH, reduced DLCO and a higher mortality risk. A VE/VCO2 slope threshold of 42 may serve as a practical prognostic marker for stratification.