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Background/Objectives Guillain-Barre Syndrome (GBS) is a polyradiculoneuropathy with an acute-subacute onset. We present a case of AMSAN that reached symptom nadir within 12 hours of symptom onset.Methods Case study and review of literatureResults A 39 year old male presented with acute onset weakness of all limbs, dysarthria and ptosis, without sensory involvement. This was preceded by a diarrhoeal illness 6 days prior.Symptoms progressed rapidly, and within 8 hours of symptom onset he was intubated. Nerve conduction studies and electromyography on day 5 found diffusely absent motor and sensory responses, and negative repetitive nerve stimulation. His stool tested positive for Campylobacter and Shigella/E coli. He received intravenous immunoglobulin and subsequently 5 cycles of plasma exchange. Subsequently, his muscle and respiratory function slowly improved and he is rehabilitating in hospital.Conclusion This case highlights the potential for GBS to progress rapidly, and the need for early intensive care involvement.