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Background The PiPPIN study defines epidemiological and phenotypic variation of syndromes associated with frontotemporal lobar degeneration (FTLD): progressive supranuclear palsy, corticobasal syndrome, behavioural-variant frontotemporal dementia and primary progressive aphasiaMethodology PiPPIN is a prospective, observational study in Cambridgeshire and Norfolk (population 1.8million 2021) with three 2-year recruitment phases: 2013-14, 2017-18 and 2021-22. Multisource referral identified people with FTLD-associated diagnoses. Contemporary international consensus clinical diagnostic criteria were applied.Results 520 participants (M:F 257:252, unknown=11; mean age 71y[ 9.4].) were recruited with FTLD-related syndromes. The diagnoses at recruitment were: PSP n=187 (36%), bvFTD n=129 (25%), PPA n=111 (21%), CBS n=93 (18%). 72% of patients had died by the census date 30/6/2024.Direct age-adjusted prevalence peaked in the seventh decade at 33/100,000. The incidence (per 100,000 population/year) and midpoint prevalence (per 100,000) for each phase were (95% CI):Pippin 1: Incidence 2.1 (1.7-2.7), Prevalence 8.8 (7.5-10.3)Pippin 2: Incidence 1.9 (1.4-2.4), Prevalence 8.9 (7.6-10.4)Pippin 3: Incidence 1.9 (1.5-2.5), Prevalence 7.4 (6.2-8.7)Median survival from diagnosis was (years [IQR]): PSP 2.8 [2.6]; CBS 3.9 [3.6]; bvFTD 4.1 [4.1]; PPA 6.0 [5.3]Ongoing Cox-regression modelling is investigating blood, imaging and clinical predictors of survival.Conclusion The incidence and prevalence of FTLD-associated disorders is stable over ten years. Survival remains poor. Determining survival predictors will help to develop therapeutic strategies.katherinestockton@nhs.net