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The Premier League is not only a global sporting spectacle but also a domain of increasing medical sophistication. As the Premier League has grown in popularity and the matches increased in intensity, so too has the complexity of player health management and clinical governance. The demands of modern football—high match frequency, evolving physical demands and global visibility—require world-class medical systems to safeguard player welfare. This context sets the scene for this special edition of the British Journal of Sports Medicine (BJSM), which highlights the latest scientific research emerging from the Premier League to advance policy and practice in player health.