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Following the success of the Federal Interagency Traumatic Brain Injury Research (FITBIR) Information System in sharing data across the entire traumatic brain injury research field and facilitating collaboration between laboratories, the Defense Health Agency’s Research and Engineering Combat Casualty Care Portfolio recognized that a data repository for general trauma research could increase the relevance and value of the data collected, benefiting trauma care, leading to significant advances in treatment, and improving outcomes in both military and civilian populations.