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Introduction Cardiopulmonary exercise testing (CPET) poses challenges in obtaining consistency in exercise protocol design as well as data processing and presentation. Furthermore, collation and interpretation of results can take a physiologist and a physician up to 40 minutes. We evaluated a novel software application (enhancedCPETanalytics™. Los Angeles, USA) that processes and organises the data from CPET in less than 10 seconds and compared determinations with clinician interpretations.Methods We selected 152 CPET studies performed in Cambridge. They were divided into seven diagnostic categories according to previous clinical interpretations. Data was collected using a metabolic cart (Vyntus™ CPX) and exported via the diagnostic software platform (SentrySuite™, Jaeger Medical GmbH, Hochberg, Germany) as spreadsheets with prespecified format. The data were blinded according to diagnostic category and processed in Los Angeles using the novel software application. Studies were analysed using the two methods by blinded investigators. Key numerical values were compared using Bland Altman statistics. Key categorical data were compared using Cohen’s kappa statistics. This investigation was approved under a data sharing agreement between our two universities. 1 2 Results The CPET studies met quality criteria in terms of protocol design and work rate control. Subjects were aged 50.9 (17.6) years and 56% were female. Statistical comparisons are shown in table 1. For numerical data we saw highly significant correlation and small mean bias by Bland Altman analysis between the two analytical methods. Identification of functional impairment, cardiovascular limitation and ventilatory limitation showed substantial to near perfect agreement by Cohen’s kappa. enhancedCPETanalytics offered additional quality criteria related to data variability.Abstract S26 Table 1Conclusions Close agreement was seen for all numerical variables and key categorical variables when comparing the novel software application with clinician interpretation. In addition, the software application has the ability to minimise subjectivity in analysis, standardise testing interpretation and improve reporting time-efficiency. These are qualities much needed for the wider acceptance and recognition of the clinical usefulness of CPET.References Cooper CB. Exercise testing does not have to be complicated. Chron Respir Dis. 2006;3:107–108.Ward SA. Exercise testing needs to be comprehensive. Chron Respir Dis. 2006;3:109.