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We read with interest the multicentre study by Guo et al, which developed a late-fusion imaging model (LFM) and a clinical-radiological model (CRM) for hepatocellular carcinoma treated with transarterial chemoembolisation (TACE).1 The multinational cohort, the external validation in Warsaw and the radiogenomic analyses are important strengths. However, several aspects of the manuscript’s clinical interpretation would benefit from clearer definition.