We hold these truths to be self-evident

Until recently, there has been an accepted dogma that nerve conduction studies in inherited dysmyelinating neuropathies show uniform conduction slowing, without conduction block or marked temporal dispersion, with most notable exceptions being hereditary neuropathy with liability to pressure palsies (HNPP) and Charcot Marie-Tooth 1X (CMT1X). However, expanding phenotypes in both the distal hereditary motor neuropathies (dHMN) and Charcot Marie-Tooth (CMT) families have challenged that and shed a more complex light on interpretation of nerve conduction studies in inherited neuropathies. The expanding phenotypes in dHMN and CMT, with previous work in sigma nonopiod intracellular receptor-1 (SIGMAR1)and phosphatidylinositol glycan anchor biosynthesis class G (PIGG) among others, illustrate the need for scrupulous review of nerve conduction studies.