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We read with great interest the recent article by Fujino et al1 evaluating the noninferiority of popliteal plexus block compared with Infiltration between the Popliteal Artery and Capsule of the Knee for posterior knee pain management after total knee arthroplasty (TKA). While the study offers intriguing insights, we would like to raise several statistical and methodological concerns that may influence the interpretation and reproducibility of its findings.