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Annotated abstract

Gastric leiomyosarcoma mimicking hepatocellular carcinoma

bmjcr · 2025-09-25 · canonical JSON source

3 visible annotations · policy: published · automated confidence ≥ 75.00%

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Gastric leiomyosarcoma is an extremely rare malignancy with an aggressive course. Complete excision of the tumour with adjuvant therapy is a curative option. The patient presents with non-specific upper gastrointestinal symptoms. Preoperative biopsy and immunostaining with endoscopic ultrasound guidance is the most accurate tool for diagnosis. We present here a case of a middle-aged man, presenting with upper abdominal heaviness and a lump which progressed rapidly in size over a few weeks, associated with appetite and weight loss. Radiographic evaluation was suggestive of a large tumour of the left lobe of the liver, possibly hepatocellular carcinoma, due to raised protein induced by vitamin K absence-II levels. Intraoperatively, it turned out to be of gastric origin, in relation to the liver.