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In patients with small intestinal Crohn’s disease (CD), there is a need for a simple, non-invasive test to reduce dependence on invasive procedures (eg, enteroscopy) and costly imaging (eg, MRI or CT enteroclysis). In an analysis of various groups undergoing different procedures (enteroscopy: n=48; MRI: n=22; CT: n=26), intestinal ultrasound (IUS) showed high concordance with device-assisted enteroscopy (DAE) for lesion localisation—100% in the mid-distal bowel and 72.7% in the distal small bowel. Adding small intestinal contrast ultrasound increased stricture detection sensitivity from 47% to 75%. Concordance with MRI/CT enteroclysis was 80% in the proximal to mid small bowel and 94.4% in the distal small bowel.