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Background and Importance Medication reconciliation is a key strategy for enhancing patient safety, particularly in surgical units where frequent care transitions increase the risk of errors. According to the World Health Organization (WHO), over 40% of medication errors are linked to inadequate reconciliation, resulting in significant morbidity and increased healthcare costs. Integrating a clinical pharmacist into surgical teams can optimise pharmacological therapy, prevent medication-related errors, and improve patient outcomes.Aim and Objectives To evaluate the impact of incorporating a clinical pharmacist into a general and digestive surgery unit, focusing on patient safety and quality of care.Material and Methods A prospective interventional study was conducted over six weeks (January–February 2025) in the general and digestive surgery unit of a regional hospital. The pharmacist-led intervention included:– Medication reconciliation at admission, during hospitalisation, and at discharge.– Pharmacotherapeutic follow–up: prescription validation, dose adjustments, antimicrobial stewardship, thromboprophylaxis review, and nutritional support.– Pharmaceutical interventions aimed at therapy optimisation.– Documentation and assessment of interventions and their clinical impact.Inclusion criteria Hospitalised patients with a length of stay >48 hours and active pharmacological treatment.Results A total of 119 patients were reviewed (mean age: 67 years; average of 11 medications; Charlson Comorbidity Index: 6).In total, 398 pharmaceutical interventions were performed, averaging 3.4 interventions per patient and 12 per day. Intervention breakdown:– 50.5% (n=201): treatment continuity issues– 7.2% (n=29): overdosing– 7.8% (n=31): sequential therapy (IV to oral switch)– 6.2% (n=25): excessive treatment duration– 2.5% (n=10): thromboprophylaxis adjustment– 25.8% (n=102): other (unnecessary therapy, untreated indications, underdosing, insufficient duration)The most impacted therapeutic areas were antibiotics, antihypertensives, antiplatelets, antidepressants, and analgesics. Pharmacist involvement reduced reconciliation errors, prevented omission of chronic treatments, and facilitated optimisation of administration routes post-surgery. A reduction in medical consultations for treatment review was also observed.Conclusion and Relevance The integration of a clinical pharmacist into surgical teams significantly improved patient by reducing reconciliation errors and optimising pharmacotherapy. Medication reconciliation should be a core strategy in surgical units to enhance care quality and minimise adverse drug events.Conflict of Interest No conflict of interest