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Introduction Simulation training in endoscopy aids learning through deliberate practice with mastery learning, expert trainer feedback and debriefing. 1 We previously showed a one day haemostasis course significantly enhanced nurse knowldege and confidence in skills in haemostasis.2 Effective colonic polypectomy ensures patient safety and reduces post colonoscopy colorectal cancer rates.3 We aimed to develop and assess impact of a practical one-day nurse polypectomy course.Methods Senior endoscopy nurse educators and endoscopists devised a one-day course focused on essential knowledge, skills and complication management for SMSA level ≤ 2 polyps matching course content was against relevant JETS workforce DOPS. Pre and post course were collected and impact measured by delegate assessment of improvement in knowledge and confidence in practical skills.Results Five courses with 66 attendees occurred: 88% female, 89% band 5 nurses, 46% had <1 year experience as an endoscopy nurse/assistant, 50% had <6 months experience in assisting polypectomy. Significant improvement in delegate self-rated knowledge and confidence in the below areas were noted.Conclusions Our nurse polypectomy course demonstrates improvement in the knowledge and confidence in practical skills of the endoscopy nurses in key areas of polypectomy. Incorporation into the JETS ENDO 2 portfolio has ensured ongoing funding for this important training offer.References Khan R, Scaffidi MA, et al. Simulation in endoscopy: practical educational strategies to improve learning. World J Gastrointest Endosc. 2019 Mar 16;11(3):209–218.Jackson T, Richardson, et al. Development and impact of an upper GI haemostasis course for endoscopy nurses. Gut 2024;73:A234–A235.Burr N, Beaton D, et al. A national audit of 1724 post-colonoscopy colorectal cancers: understanding causes and consequences. Endoscopy. DOI: 10.1055/a-2681-5642Abstract O37 Table 1Pre-Course Median (n=66)Post Course Median (n=66)p-valueDelegate self rated knowledge of the following:Risks of polypectomy and EMR3.0005.000<0.0001Importance of individualised consent process for EMR3.0005.000<0.0001The natural history of polyp progression2.0005.000<0.0001Assessing the cancer risk of a polyp2.0005.000<0.0001Understanding why polyp resection methods differ between polyp2.0005.000<0.0001Safe management of implantable cardiac devices2.0005.000<0.0001Diathermy for polypectomy/EMR3.0005.000<0.0001Management advice for the patient after polypectomy/EMR3.0005.000<0.0001Delegate self assessment in ability to undertake:Pre-assessment for colonoscopy and polypectomy/EMR2.0004.000<0.0001Consent for EMR2.0004.000<0.0001Cold snare polypectomy3.0005.000<0.0001Marking a snare3.0005.000<0.0001Hot snare polypectomy3.0005.000<0.0001Hot snare EMR3.0005.000<0.0001Therapy for post polypectomy bleeding2.0005.000<0.0001Roth net retrieval of polyps3.0005.000<0.0001Tattoo placement3.0005.000<0.0001