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Aging vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of several age-associated cardiovascular conditions such as atherosclerosis. However, studying cellular aging in humans remains challenging due a lack of suitable in vitro models. To meet this need, we have created an ‘aging-in-a-dish’ VSMC model using induced pluripotent stem cell (iPSCs) derived from a patient with Hutchinson-Gilford Progeria Syndrome (HGPS), a premature aging disorder caused by accumulation of the protein progerin, a mutant form of the nuclear lamina component lamin A. HGPS patients display multiple characteristics of cardiovascular aging including the premature development of atherosclerosis. We hypothesise that insights from HGPS can inform the development of targeted therapies and preventative strategies for age-associated vascular diseases. We used CRISPR-Cas9 gene editing to correct the disease-causing LMNA mutation in HGPS-iPSCs, creating an isogenic control cell line, which we then used to generate VSMCs of the lateral plate mesoderm lineage: a cell type relevant for several vascular pathologies including atherosclerosis. RT-PCR and immunoblotting confirmed expression of progerin was ameliorated in isogenic control VSMCs. Extensive characterisation of HGPS-VSMCs showed detectable signs of accelerated aging including increased expression of inflammatory cytokines, epigenetic alterations (reduced H3K9me3) and dysmorphic nuclei which were all reduced in CRISPR-corrected VSMCs. Bulk RNA sequencing analysis highlighted alterations in extracellular matrix production (ECM), and analysis of publicly available datasets confirmed similar ECM alterations occur in physiologically aged VSMCs. However, such changes are difficult to recapitulate in 2D cultures. To overcome this limitation, we are developing 3D engineered vascular tissues to model changes in ECM dynamics in HGPS-VSMCs with the aim to perform proteomic analyses. This model may identify potential new therapeutic targets in accelerated and physiological aging whilst providing a platform for drug testing with higher physiological relevance than a 2D monoculture.