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Background and Objectives Tumors involving dural venous sinuses can lead to venous outflow obstruction and secondary intracranial hypertension. While surgical resection can decompress the sinus, such procedures carry significant risks. Venous sinus stenting (VSS) and angioplasty have emerged as potential treatments for tumor-related sinus stenosis. However, evidence remains limited. This systematic review aimed to synthesize the available literature on the safety and efficacy of endovascular treatment for tumor-related venous sinus obstruction.Methods A systematic search of PubMed, Embase, and Web of Science was conducted. Eligible studies included any report describing endovascular treatment (VSS and/or angioplasty) for tumor-related venous sinus obstruction. Data on patient demographics, tumor characteristics, procedural details, and outcomes were extracted and summarized descriptively.Results Twenty studies comprising 57 patients were included. Most patients were female (65%) with a mean age of 48 years. Most patients underwent VSS alone (74%), while the rest underwent VSS and angioplasty (23%). No periprocedural complications were reported. Mean trans-stenotic pressure gradient decreased by 10 ± 9 mmHg post-treatment and mean lumbar opening pressure decreased by 11 ± 12 cmH2O. Clinical improvement was reported in 63% of patients, including resolution or improvement of papilledema in 94% and vision changes in 94%. Repeat intervention was required in 28% of cases, and half of patients achieved further improvement after reintervention.Conclusion Endovascular therapy for tumor-related venous sinus stenosis appears can lead to meaningful pressure reduction and symptomatic improvement in most patients. Further research is needed to establish the role of VSS in the context of tumor-related venous outflow obstruction.Disclosures V. El-Hajj: None. M. Gharios: None.