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Adjusting vancomycin dosing based on renal function estimation equations is critical to physicians and clinical pharmacists for the successful treatment of methicillin-resistant Staphylococcus aureus (MRSA) in hospital. Vancomycin remains a cornerstone of that armamentarium, yet its narrow therapeutic window and the heterogeneity of renal function among infectious patients make adjusting vancomycin dosages to effectively treat infections difficult. Currently, there is no relevant report comparing the accuracy of several renal function estimation equations in predicting the minimum vancomycin concentration, yet the use of these equations is crucial for precisely adjusting vancomycin dosages to effectively treat infections while preventing renal damage in patients. The retrospective study by Gratacós and Soy-Muner,1 gives us the clearest evidence to date that the equation chosen to estimate renal function is not a trivial detail—it is the pivotal step that decides whether the next dose will save the patient or injure the kidney.