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Syngnathia is a congenital condition characterised by fibrous and/or bony fusion between maxilla and mandible. We report the case of a neonate who underwent surgical release of syngnathia under general anaesthesia. Management required multidisciplinary planning involving surgeons, anaesthesiologists and paediatricians, spanning pre-operative assessment through postoperative care. Prior to surgery, availability of neonatal intensive care unit (NICU) bed and appropriate airway equipment-including a fibreoptic bronchoscope sized for neonate was ensured. This case highlights the importance of tertiary-level healthcare facilities with coordinated multidisciplinary team, advanced airway management capabilities and a well-equipped NICU staffed by trained personnel for management of rare and difficult cases.