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Background Prescribing is responsible for over half of carbon emissions in primary care.Strategies to reduce unnecessary medication use are therefore important in supporting the delivery of a net-zero National Health Service (NHS).Methods We ceased to accept pharmacy-managed repeat prescriptions and undertook a patient education campaign to order only the medication they needed.Results The intervention was associated with a saving of £165 957 and 5350 fewer prescribed items over a 7-month period. This equated to estimated emissions savings of 96 421 kgCO2e.Conclusions A well-planned campaign to move away from pharmacy-managed repeat prescriptions to patient-initiated requests can reduce prescribing costs and support the NHS journey to net zero.