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Background and Importance Drug-related problems (DRPs) are a major concern in hospitalised patients, as medication errors can occur at any stage, including prescribing. The previous inpatient pharmacy system lacked continuous follow-up, resulting in inappropriate prescribing such as incorrect antibiotic dosing, contraindicated or duplicate medications, and use without proper indications. Several incidents were reported with severity levels C and D. To address this, pharmacists implemented a proactive monitoring system using the IPD paperless program (KPHIS) to review laboratory results and medication profiles every 5 days, consulting physicians as needed to resolve identified DRPs.Aim and Objectives The purpose of this study was to evaluate the impact of a proactive prescription screening system by pharmacists on the detection of drug-related problems (DRPs) and on the clinical impact of pharmacist interventions in hospitalised patients.Material and Methods A prospective research and development study was conducted in the ICU, internal medicine and surgery and orthopaedics wards from 1 October 2024, to 30 April 2025. DRPs were categorised according to the Pharmaceutical Care Network Europe classification (PCNE) classification. The impact of pharmacist intervention (PIs) based on standard pharmacist assessments, was evaluated using the clinical, economic, and organisational (CLEO) tool.Results During the study period, 1,838 patients were screened. 135 DRPs were detected and managed, representing 7.34% of all cases. The types of DRPs were treatment effectiveness (65.19%), other (23.70%), and treatment safety (11.11%). The top three possible causes of DRPs were drug selection (46.67%), dose selection (32.59%), and patient transfer-related issues (12.59%). The severity of the problems was categorised as C and D in 68.89% and 14.07% of cases, respectively. The overall acceptance rate by physicians was 97.39%. Eighteen pharmacist interventions (PIs, 13.33%) had major clinical impact and 74 PIs (54.81%) had moderate clinical impact. A positive economic impact was observed in 57.78% of cases, leading to savings in drug costs.Conclusion and Relevance The proactive prescription screening system implemented by pharmacists effectively detected and managed DRPs in hospitalised patients. Pharmacist interventions had high physician acceptance, significant clinical impact, and contributed to drug cost savings. These findings highlight the important role of pharmacists in improving patient safety and optimising therapy.Conflict of Interest No conflict of interest