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Aim Our Trusted Research Environment (TRE) provides a centralised infrastructure to pool Longitudinal Population Studies’ (LPS) data and systematically link participants’ routine health, administrative and place-based records. UK LLC is a globally unique longitudinal resource – supporting health and social science research and enabling research responses to emerging situations as well as policy needs.Methods We have created an unprecedented infrastructure integrating data from interdisciplinary and pan-UK LPS linked to participants’ health, administrative and place-based records. UK based researchers can apply to access all these data via a single application. Integrated and curated data are made available for pooled analysis within a functionally anonymous Digital Economy Act and ISO 27001 accredited TRE. We developed a bespoke governance and data curation framework with data providers, LPS data managers and public/participant contributors. New data pipelines are being built with partners at Administrative Data Research UK and the Office of National Statistics to link administrative records. Our design supports long-term sustainability, linkage accuracy and the ability to link data at both an individual and household level.Results This organisation is a collaboration of over 20 of the UK’s most established LPS with over 325,000 participant records. Participants’ data are linked to NHS records and place based exposures. This resource is now accessible for public benefit research for bona fide UK researchers. Administrative data including tax, work and pensions, and education are being added to the resource throughout 2025–26. This data flow is enabled by: (1) a model where a Trusted Third Party processes participant identifiers for many different data owners; (2) creation of a novel longitudinal data pipeline, enabling linkage, data extraction and update of records over time; (3) an access framework where a Linked Data Access Panel considers applications on behalf of data owners (e.g., the NHS), with review by a public panel and distributing applications to LPS for approval.Conclusion UK LLC provides a simple-to-access strategic research-ready platform for longitudinal research. We are extending linkages of LPS participants to previously inaccessible datasets. The research resource is positioned to allow researchers to investigate cross-cutting themes such as understanding health and social inequalities, health-social-environmental interactions, and managing the COVID-19 recovery. The greater availability of large scale, diverse linked data will help provide the numbers for researchers to study rarer outcomes and seldom-reached populations.