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We read with great interest the article entitled ‘Nomogram for predicting early neurological deterioration in patients with mild large and medium vessel occlusion stroke intended for medical management: a multicenter retrospective study’ by Qiu et al.1 The authors have conducted an important study, aimed at developing and validating nomograms for predicting the risk of early neurological deterioration (END) in a specific patient population—a commendable endeavor. However, we have some comments and suggestions that may help clarify some of the results and enhance the usefulness of the article for readers.