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Annotated abstract

Loss of sinusoidal endothelial identity: RAP1A at the crossroads of capillarisation and liver fibrosis

gutjnl · 2026-04-15 · canonical JSON source

8 visible annotations · policy: published · automated confidence ≥ 75.00%

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Liver fibrosis represents a serious worldwide health issue with a prevalence of around 5% in general populations.1 The most relevant aetiologies of liver fibrosis include metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD) and chronic hepatitis B and C infections. Persisting liver fibrosis can lead to irreversible liver cirrhosis with fatal complications such as ascites, variceal haemorrhage and acute-on-chronic liver failure.