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Background and Aims Christmas festive period has been associated to mood disorders and depression, especially in certain specific populations. Aim of the study was the observation and recording of pain scores fluctuation in chronic non-cancer patients, during that corresponding time period.Methods After Hospital’s Ethics Committee Apptoval, and patients consent were granted, a questionnaire - record was formed including patients‘ demographics, with empahasis in their way of living (alone or with other people, work, living environment, financial situation, and any possible psychotraumatic incidents), pain condition, usual pain scores, pain medication, history, other medication, and clinical examination. Afterwards, patients were assigned to groups according to their age, gender, and way of living (alone, in assisted care institutions, or with spouses, partners, friends or care-takers). Parameters recorded, were pain scores, needs for extra phone or in hospital consultation and modification in their pain medication, and their differences between Christmas celebration and rest periods of year.Results Among 176 regular (at least one pain clinic consultation per trimester for 18 months period, November 2023-April 2025) pain clinic patients demonstrating chronic non-cancer pain, were eligible for the study. Records’ analysis demonstrated statistically significant (p<0.01) increase in patients‘ visits (32–76%) and telephone colsultations (38–86%), pain scores (+3,4 VAS, 65–88%), and analgesic medication needs (+45–126%), with a significant increase in opioid consumption, during Christmas period (±10 days December 25th). Most affected patients groups were between 55–64 (67%) and >65 (89%). Statistically significant increase in recorded parameters were also observed in patients living alone, unemployed, facing financial problems (72–100%)Conclusions Our results demonstrate that during Christmas festive period, a significant increase in pain scores has been observed in patients with chronic non-cancer pain, especially in elederly and lonely living ones. Further studies are needed to support these findings and conclusions, and maybe to discover a way of prevention and therapy of this situation.