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Catheter-related bloodstream infections (CRBSI) are a life-threatening complication in children who require long-term parenteral nutrition (PN). 1 The CRBSI rate for our centre was 1.17/1000 catheter days between 1st October 2022 and 1st October 2023.2 This was a follow-up study to assess our current infection rate.Patients enrolled in the centre’s tertiary intestinal failure (IF) rehabilitation home PN service from 1st October 2024 to 1st October 2025 were included. Information regarding infections and potential risk factors for CRBSI were prospectively recorded.42 patients were included. Half of the patients were female, and the median (25th-75th Q.I.) age was 10 (5.75-15) years. PN was initiated primarily for short bowel syndrome (45.2%), followed by gastrointestinal motility disorders (40.5%), intestinal mucosal diseases (9.5%) and immune-haem-oncological disorders (4.8%). Unlike the previous study, no patients in this cohort received PN due to severe neurodevelopmental impairment. 7/42 (16.7%) patient families on home PN were identified as vulnerable with difficulty prioritising their child’s health needs, which resulted in a delayed presentation of suspected CRBSI. Patient characteristics are shown in table 1.10 episodes of CRBSI occurred among 5/42 (11.9%) patients, with one patient experiencing two episodes and two patients having three episodes each. The median (25th-75th Q.I) age of patients with CRBSI was 6 (2.5-8.5) years. 3/5 (60.0%) patients with CRBSI were female, with 1/5 (20.0%) patients coming from a vulnerable family.The overall CRBSI rate was 0.72/1000 catheter days, with no significant reduction compared to the previous infection rate of 1.17/1000 catheter days (p=0.18). When separated by diagnosis, the CRBSI rates were 0.92/1000 catheter days for short bowel syndrome, 0.87/1000 for mucosal disorders and 7.14/1000 for immune-haem-oncological disorders. There were no infections among home PN patients with gastrointestinal motility disorders. Factors such as family vulnerability, gender, use of gloves during central venous catheter (CVC) care, and TauroLock administration did not significantly influence infection rates. The CRBSI rate among patients from vulnerable families significantly decreased from 3.86 to 1.39/1000 catheter days (p = 0.049).In summary, our CRBSI rate of 0.72/1000 catheter days was lower than previously reported. Infection rates also improved amongst patients from vulnerable families, possibly due to additional support provided by the clinical team to those identified as high risk. In contrast to previous studies, family vulnerability, gender, the use of gloves during CVC care, and TauroLock use were not associated with changes in infection rates in this cohort. These results suggest that current practices are effective, supporting their continued implementation to reduce CRBSI rates in paediatric IF patients on home PN.References Puoti MG, D’Eusebio C, Littlechild H, King E, Koeglmeier J, Hill S. Risk factors for catheter-related bloodstream infections associated with home parental nutrition in children with intestinal failure: a prospective cohort study. Clin Nutr 2023;42:2241–2248.Littlechild H, Montgomery-Stuart S, Mari A, et al. OC91 Trends in catheter related blood stream infections rates in children on home parenteral nutrition. Frontline Gastroenterol 2024;15:A61–A62.Abstract OC47 Table 1Characteristics of children in the home PN programmen%Total patients42Females2150.0Recorded episodes of infections (hospital-acquired)550.0Short bowel syndrome1945.2Gastrointestinal motility disorders1740.5Intestinal mucosal diseases49.5Immune-Haem-Oncological disorders24.8Severe neurodevelopmental impairment00.0Vulnerable families*716.7Central venous catheter care with gloves1535.7Single lumen3788.1Central line3890.5Taurolock3071.4*Psycho-social issues interfering with ability to prioritise PN care