Document resource
Background Comorbidities influence dengue disease progression, yet their specific effects on hospitalization duration in dengue with warning signs (DWS) remain poorly characterized. This study aimed to evaluate comorbidity patterns and their distinct associations with clinical prognosis in hospitalized DWS patients.Methods We retrospectively analyzed 732 DWS inpatients admitted to Foshan Fourth People’s Hospital from July to November 2024. Demographics, comorbidity profiles, and laboratory parameters were collected. Multivariate linear and ordered logistic regression models were employed to identify independent predictors of hospitalization duration.Results Comorbidities were highly prevalent (71.86%), with liver disease being the most common (45.63%), followed by cardiovascular disease (22.95%), renal disease (22.64%), and hypertension (18.99%). Regression analysis revealed that hypertension (OR=1.685, 95% CI: 1.118-2.54, P=0.013), cardiovascular disease (OR=1.742, 95% CI: 1.219-2.492, P=0.002), neurological conditions (OR=3.837, 95% CI: 1.525-9.653, P=0.004), and infectious diseases (OR=2.165, 95% CI: 1.414-3.314, P<0.001) significantly prolonged hospitalization. Notably, despite its highest prevalence, liver disease showed no significant association with extended hospital stay (P>0.05), similar to diabetes and renal disease ( IDDF2026-ABS-0318 Figure 1. Comorbidities significantly correlated with length of hospital stay). Patients with liver disease exhibited elevated alanine aminotransferase levels when concurrent with digestive symptoms (t=-2.229, P=0.026), yet this hepatic involvement did not translate into prolonged hospitalization. These findings suggest that liver disease may primarily influence severity progression to severe dengue rather than directly extending the warning signs phase, whereas cardiovascular and neurological comorbidities impose distinct burdens requiring extended inpatient management.Conclusions Comorbidity-specific risk stratification is essential in DWS management. While liver disease is most prevalent, cardiovascular and neurological conditions are stronger predictors of prolonged hospitalization, highlighting the need for tailored monitoring strategies based on comorbidity type rather than mere presence.Abstract IDDF2026-ABS-0318 Figure 1