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Background and Importance Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn’s disease, is a chronic disorder of the gastrointestinal tract with multifactorial aetiology. Its impact significantly compromises patients’ quality of life, affecting physical, psychological, and social domains. Among the available therapeutic options, anti-TNFα monoclonal antibodies such as infliximab (IFX) and adalimumab (ADA) are widely used in moderate-to-severe IBD.Aim and Objectives The primary objective of this study was to assess quality of life in patients receiving intravenous IFX or subcutaneous ADA. Secondary objectives included comparing quality of life between both therapies and evaluating treatment adherence.Material and Methods We conducted a single-centre, prospective, observational study between April and June 2025. Adult patients with a confirmed diagnosis of moderate-to-severe IBD treated with IFX or ADA for at least 1 year were included. Exclusion criteria comprised severe comorbidities, cognitive impairment, or inability to complete questionnaires.Quality of life was assessed using the validated IBDQ-9, while adherence was measured through the Morisky 4-item scale for ADA and infusion attendance for IFX. The study was approved by the Institutional Research Ethics Committee, and all participants provided informed consent. Statistical analysis included measures of central tendency and dispersion for quantitative variables, and absolute frequencies for categorical variables. Independent samples t-test was used for mean comparisons, with significance set at p<0.05. Analyses were performed with SPSS v.24. Data sources included electronic medical records and the outpatient dispensing module.Results A total of 70 patients were included: 36/70 (51.4%) treated with IFX and 34/70 (48.5%) with ADA. The mean age was 50.9 years (SD=13.4), with Crohn’s disease predominating (78.6%). Overall IBDQ-9 scores indicated good quality of life (69.5%, SD=22.1%). No significant differences were observed between therapies (p=0.92), although IFX showed a higher proportion of patients with very good quality of life. Adherence was 100% in IFX versus 85.3% in ADA. Notably, non-adherent ADA patients reported nearly 30% lower quality of life compared to adherent patients.Conclusion and Relevance Patients with IBD treated with IFX or ADA demonstrated overall good quality of life, with no significant differences between therapies. However, treatment adherence emerged as a key determinant, particularly in patients receiving ADA.Conflict of Interest No conflict of interest