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Colorectal cancer (CRC) represents a major global health issue, ranking as the third most common tumour and the second leading cause of cancer-related mortality worldwide.1 Distant metastasis is the primary cause of fatality for patients with cancer. CRC often presents as metastatic disease at diagnosis, and up to 70% of patients who undergo curative surgery of the primary tumour will eventually develop metastases. The liver is the most common site for CRC metastatic spread. Despite significant progress in surgical interventions and treatments, a large number of patients with CRC have inoperable liver metastases or experience recurrence after surgery. To develop new therapeutic strategies and improve the management of advanced CRC, a deep understanding of the metastatic process is of utmost importance.