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As part of the special Journal for ImmunoTherapy of Cancer (JITC) series, “Myeloid Cells in Immuno-Oncology,” leading experts were asked to provide their perspectives and answer provocative questions on controversial and evolving areas in the field of myeloid biology. Their responses below aim to further the discussion and help advance the biological understanding of myeloid cell biology within the tumor and strategies to modulate the function and activity of myeloid cells for anticancer therapy.