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Free-living amoebae like Naegleria fowleri, Acanthamoeba or Balamuthia mandrillaris are rare causes of central nervous system infections. Naegleria fowleri causes primary amoebic meningoencephalitis, whereas the latter two cause granulomatous amoebic encephalitis, which usually occurs in immunocompromised people and is almost universal fatal despite treatment. Early diagnosis is challenging due to the non-specific neurological symptoms, and there are no specific treatment guidelines. We report a case of successfully treated relapsing Acanthamoeba encephalitis in an immunocompetent individual.