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Description To provide sustainable, quality care, health systems must design interventions to support high-utilizing patients. Demonstrating the return on investment (ROI) and return on health (ROH) of these programs to leaders with competing priorities is crucial.Our simple approach to calculate ROI and ROH focuses on avoidable Emergency Department (ED) visits, hospitalizations, and length of stay (LOS), keeping patients healthier and enhancing access for lower cost and more highly reimbursed visits. Participants will practice this framework through a simulation.Working with finance, we found that ED visits and hospitalizations by high-risk patients had a lower average contribution margin and net revenue compared to the general patient population, and used this cost differential as a multiplier to estimate cost savings.We assessed the ROI of a care pathway for Chronic Kidney Disease and Heart Failure, projecting a total annual increase in contribution margin of $1.15 million and a net gain of $857,000 related to a 10% reduction in avoidable visits and 0.5 reduction in LOS when those beds are backfilled with patients from the general population.This framework is an approachable method to make a financial and clinical case for high-risk programs. Working in close collaboration with our finance team helped achieve executive buy-in.