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Introduction A new access catheter system (Zebra, Q’Apel Medical, Inc.), based on laser-cut tube technology, was generated to reduces the catheter wall thickness, thereby increasing the inner catheter diameter (ID) while maintaining the outer diameter (OD) and the necessary support and trackability for radial access.Aim of Study Multi-center registry analysis of the new radial catheter system ZebraMethod Patients enrolled in this multi-center registry underwent various ischemic and hemorrhagic stroke procedures using either the 6F (ID 0.074’) or 7F (ID 0.087’) Zebra access catheter. Prospectively collected data included basic procedural information, technical success, and periprocedural complications.Results A total of 85 patients (47 female, median age 66) were included, with procedures performed using both the 6F (n=44) and 7F (n=41) Zebra access catheters. Among 81 procedures, wrist artery access was used in 67 patients. In all procedures, the target location was reached except in two cases, where challenging arch anatomy required conversion to femoral access. Zebra catheter use was successful in both conversions. No complications related to the Zebra catheter were observed. For ischemic stroke procedures (n=18), complex aneurysm treatment (n=17) and carotid artery stenting (n=7) the 7F catheter was used to allow for the larger ID.Conclusion This initial multi-center experience demonstrates the feasibility and safety of the Zebra 6F and 7F access catheters across a variety of neurovascular pathologies. With a larger ID for the same OD, this new catheter system offers a promising advancement in many neuro-interventions.Conflict of Interest Yes Jan-Karl Burkhardt is a consultant for Q`Apel