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Objectives To compare Systemic Lupus Erythematosus (SLE) patients’ assessment of disease activity, using the Quick Systemic Lupus Activity Questionnaire (Q-SLAQ,) with physicians’ assessment of disease activity in the Swedish Rheumatology Quality register (SRQ).Methods Patients with SLE and at least one healthcare contact registered in SRQ since the Q-SLAQ was implemented were included in the analysis.The Q-SLAQ captures patient-reported of 18 symptoms (each 0-3). Additionally, patients global assessment and perceived disease activity (Q-SLAQ disease activity, 0-10). Q-SLAQtotal (range 0-34) and Symptom score (range 0-18) was calculated [Svenungsson 2021, Lupus Sci Med. 2021].Physician’s assessment of disease activity (none, low, moderate, high, maximum, converted into numeric rating scale (NRS) 0 – 4, SLE disease activity index (SLEDAI-2K) and clinical SLEDAI (cSLEDAI) was used. For comparative analyses independent samples median tests and Mann-Whitney U were used, and for correlations Spearman’s rho.Results 1846 patients (88% women) and 3828 visits were recorded with assessment of disease activity by physician or patient. At the last registered visit, median age was 51 years and median disease duration 10.5 years. Disease activity was low; NRS (median 1) and cSLEDAI (median 4) ( table 1). Out of the 437 visits including an assessment with SLEDAI-2K, 66% were below SLEDAI-2K 6. The physicians’ disease activity (NRS) discriminated for increased value on the Q-SLAQ disease activity, Q-SLAQtotal and Symptom score respectively, except for the small group with high disease activity (NRS)(n=45) (figure 1). The patients with low disease activity (SLEDAI-2K <6 or cSLEDAI <6) had lower values on the patients Q-SLAQtotal, Symptom score and the Q-SLAQ disease activity, compared to those with high disease activity (SLEDAI2K >5 or cSLEDAI >5) (p < 0.005 for all). Correlations between physicians and patients’ assessment were week, but strongest for NRS and Q-SLAQ disease activity (rho=0.38) (table 1).Abstract PO:13:333 Table 1Participants characteristics and assesmentsAbstract PO:13:333 Figure 1Patients results of Q-SLAQ disease activity (A), Q-SLAQtotal (B) and Symptom score (C) in relation to physicians’ disease activity NRSConclusions In this, first study using the Q-SLAQ with internet-based data, collected in real-life clinical practice, the patients with low disease activity had had lower values on the patient’s assessment by Q-SLAQ. Few patients had high disease activity in this sample, thus further studies are needed to assess the tool’s ability to discriminate in such cases.